SRSF6 poison cassette exon splicing as hypoxia response

Poison cassette exon splicing of SRSF6 regulates nuclear speckle dispersal and the response to hypoxia

The effect of SRSF6 poison cassette exon splicing in hypoxia

Hypoxia induces massive changes in alternative splicing (AS) to adapt cells to the lack of oxygen. In this project SRSF6 was found to be a key factor in the AS response to hypoxia. A strong reduction in SRSF6 levels in acute hypoxia led to exon skipping and triggered nuclear speckle dispersal as a mechanism for the cell to reprogram the gene expression profile. We found this mechanism to be active in various cancer types and further propose a tumor suppressor function.

The full manuscript can be found at Nucleic Acids Research.